The Gut-Organ Axis

Gut-Organ Axis: An overview of the communication (‘cross talk’) between the gut and other organs.

It is well established that the gut can communicate with other organs in the body. This communication is bidirectional via different communication channels which include:

1. The nervous system, including the central nervous system and the peripheral nervous system (including the enteric nervous system)
2. The circulatory system
3. The mucosal immune system (including gut-associated lymphoid tissue; GALT) and lymphatic system.

The science behind how they communicate and the impact of that communication on our health is still unravelling.

Explore the science behind the different gut-organ axis and highlight the different levels of evidence that exist behind each one:

• Gut-brain:
• Understanding the gut-brain axis in Parkinson’s disease
• Gut-Brain Axis and Mental Health: Beyond Anti-Depressants
• Eating Disorders and the Gut Microbiome
• Gut-heart:
• The Gut-Heart Axis: role of the gut microbiome in cardiovascular diseases
• Gut-lung:
• Hayfever and the Gut Microbiome
• Gut-liver:
• Gut-liver axis in health and perturbations in chronic liver disease
• Gut microbiome as a therapeutic target in chronic liver diseases
• Gut-urinary tract:
• Mechanism of urinary tract infections and the role of microbes
• Gut-reproductive system:
• The Gut Microbiome in Reproductive Health
• The estrobolome
• Gut-skin:
• The gut microbiome in skin health

References

1. https://asm.org/Articles/2023/January/Gut-Microbiome-Communication-The-Gut-Organ-Axis